Detalhe da pesquisa
1.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell
; 185(4): 712-728.e14, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35063084
2.
Variation in Mesenchymal KITL/SCF and IGF1 Expression at Middle Age Underlies Steady-State Hematopoietic Stem Cell Aging.
Blood
; 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38598841
3.
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
PLoS Biol
; 17(2): e3000134, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735499
4.
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Proc Natl Acad Sci U S A
; 115(40): 10172-10177, 2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232263
5.
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.
Bioorg Med Chem Lett
; 26(6): 1624-1628, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26869193
6.
3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability.
Bioorg Med Chem Lett
; 25(17): 3654-7, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26141772
7.
Werner coordination chemistry and neurodegeneration.
Chem Soc Rev
; 42(4): 1836-46, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22952002
8.
New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.
Alzheimers Dement (N Y)
; 10(1): e12458, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38469553
9.
Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.
bioRxiv
; 2023 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36909528
10.
Translational approaches to understanding resilience to Alzheimer's disease.
Trends Neurosci
; 45(5): 369-383, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35307206
11.
Leveraging genetic diversity in mice to inform individual differences in brain microstructure and memory.
Front Behav Neurosci
; 16: 1033975, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36703722
12.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sci Transl Med
; 13(622): eabe3947, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851693
13.
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.
Bioorg Med Chem Lett
; 20(7): 2137-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20202840
14.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Sci Rep
; 10(1): 13688, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32792571
15.
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.
Curr Opin Neurobiol
; 48: 52-58, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29028540
16.
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Sci Transl Med
; 9(385)2017 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28404863
17.
Synthesis, characterization, and cytotoxicity studies of Cu(II), Zn(II), and Fe(III) complexes of N-derivatized 3-hydroxy-4-pyridiones.
J Inorg Biochem
; 132: 59-66, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24393377
18.
3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.
Metallomics
; 6(2): 249-62, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999879
19.
Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.
Mol Biosyst
; 9(4): 792-805, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23435553